VDJdb

VDJdb is a curated database of T-cell receptor (TCR) sequences with known antigen specificities. The primary goal of VDJdb is to facilitate access to existing information on T-cell receptor antigen specificities, i.e. the ability to recognize certain epitopes in a certain MHC contexts.

Our mission is to both aggregate the scarce TCR specificity information available so far and to create a curated repository to store such data. In addition to routine database updates providing the most up-to-date information fetched from recently published studies utilizing TCR specificity assays, we make our best to ensure data consistency and correct irregularities in TCR specificity reporting with a complex database validation scheme:

• We take into account all available information on experimental setup used to identify antigen-specific TCR sequences and assign a single confidence score to highlight most reliable records at the database generation stage.
• Each database record is also automatically checked against a database of V/J segment germline sequences to ensure standardized and consistent reporting of V-J junctions and CDR3 sequences that define T-cell clones.

The web application you are viewing right now can be used to browse and query the database, providing an intuitive interface for database navigation. Additionally, it can be used to query immune repertoire sequencing (RepSeq) samples against the database and generate sample-level summary of detected antigen specificities.

Click on the item in the menu above to proceed:

• The Browse section allows interactive browsing and running complex database queries.
• If you want to upload your RepSeq samples/perform batch queries, you can use the Annotation section.
• If you want to browse the database of high-quality curated CDR3 motifs specific to different epitopes use the Motif section.
• For more information on VDJdb and downstream analysis tools, citation information and contacts please visit the About section.